Abcam, ab153211, Recombinant Human GP210 protein

Size: 10µg
Recombinant Human GP210 protein is a Human Full Length protein, in the 1 to 967 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q8TEM1,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GP210 also known as Nup210 is a critical component of the nuclear pore complex with a molecular mass of approximately 210 kDa. This integral membrane protein is primarily expressed in the nuclear envelope of eukaryotic cells. GP210 plays a significant mechanical role in the structural integrity of the nuclear pore complex a pivotal gateway for nucleocytoplasmic transport. Its localization at the nuclear envelope suggests its importance in maintaining the selective barrier and facilitating transport functions between the nucleus and the cytoplasm.
Biological function summary
GP210 is involved in the regulation of nuclear-cytoplasmic transport and acts as a scaffold for various transport machinery components. As a member of the nuclear pore complex it interacts with other nucleoporins forming a channel that allows the passage of molecules between the nucleus and cytoplasm. GP210 participates in processes related to genome regulation influencing gene expression by modulating nuclear import/export cycles. Alterations in GP210 function can have implications for the cell cycle and differentiation processes.
Pathways
GP210 engages in the nucleocytoplasmic transport pathway which is essential for the transport of macromolecules such as RNA and proteins. This pathway is closely related to the Ran GTPase cycle where GP210 plays a supporting role in maintaining the directionality of the transport. It interacts with transport factors such as importins and exportins ensuring the precise regulation of molecular traffic. GP210's involvement ties it to key cellular functions and highlights its critical role in cellular homeostasis and signal transduction.
Aberrant function or expression of GP210 has been implicated in autoimmune diseases such as primary biliary cholangitis (PBC). Autoantibodies against GP210 are often detected in patients with PBC indicating its role in the pathogenesis of this autoimmune liver disorder. Furthermore GP210 is associated with certain cancer types where its dysregulation might contribute to tumorigenesis and cancer progression. In these contexts GP210 could interact with oncogenic or tumor suppressor proteins highlighting its potential as a biomarker and target for therapeutic intervention.