Abcam, ab153806, Anti-Alpha 1 Microglobulin antibody

Size: 100µL
Rabbit Polyclonal Alpha 1 microglobulin antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Protein AMBP aa 1-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Protein AMBP aa 1-300. The exact immunogen used to generate this antibody is proprietary information.P02760

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Alpha 1 Microglobulin also known as A1M is a small glycoprotein with a molecular mass of approximately 26-31 kDa. This protein is expressed in the liver and then secreted into the bloodstream where it circulates throughout the body. A1M belongs to the lipocalin protein family and is involved in various protective roles due to its antioxidant properties. It has a structure that allows it to bind small molecules making it suitable for transporting and neutralizing harmful substances in the body.
Biological function summary
Alpha 1 Microglobulin functions as a radical scavenger and protects tissues from oxidative damage. It is not part of a larger molecular complex but acts individually to bind free heme and other oxidants preventing them from causing cell damage. Its regulation and expression are closely tied to cellular responses to oxidative stress making it an essential component in maintaining cellular homeostasis and physiology under stress conditions.
Pathways
Alpha 1 Microglobulin plays a role in the heme degradation and detoxification pathways. It interacts with proteins such as haptoglobin which also participates in the clearance of free hemoglobin. Through its involvement in these pathways A1M helps mitigate oxidative stress and contributes to the protection of the vascular system against damage. This capacity to interact with other proteins in these pathways highlights its importance in tissue protection and inflammation modulation.
Alpha 1 Microglobulin has been implicated in conditions such as preeclampsia and chronic kidney disease. During preeclampsia the protein helps to counteract the increased oxidative stress associated with the disorder; its interaction with the protein hemopexin further supports the removal of free heme in the bloodstream. In chronic kidney disease the concentration of A1M in the urine may increase indicating kidney damage and oxidative stress. These connections emphasize the potential for A1M as a biomarker or therapeutic target in managing oxidative stress-related conditions.