Abcam, ab153815, Anti-GALK2 antibody

Size: 100µL
Rabbit Polyclonal GALK2 antibody. Suitable for WB, ICC/IF, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human GALK2 aa 50-350.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human GALK2 aa 50-350. The exact immunogen used to generate this antibody is proprietary information.Q01415

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein known as GALK2 also referred to as galactokinase 2 functions mechanically as a kinase that phosphorylates galactose and N-acetylgalactosamine. This enzyme is a part of the Leloir pathway of galactose metabolism. The GALK2 gene encodes the protein which has a molecular mass of approximately 50 kDa. Its expression primarily occurs in the cytoplasm with notable levels found in liver kidney and pancreas tissues. GALK2 is important for catalyzing the transfer of a phosphate group to the sugar substrates which is an important step in their metabolism.
Biological function summary
The protein plays a role in maintaining the homeostasis of galactose and N-acetylgalactosamine levels within the cell. As an enzyme involved in the metabolism of sugars GALK2 helps to convert galactose and its derivatives for energy production and biosynthetic pathways. Although GALK2 does not form large complexes it interacts with other enzymes in the Leloir pathway to facilitate efficient biochemical transformations. These interactions assist in regulating the flow and conversion of substrates through metabolic pathways.
Pathways
The involvement of GALK2 can be primarily ascribed to the galactose metabolic pathway which is essential for processing dietary galactose into glucose-1-phosphate. This pathway also includes enzymes such as galactose-1-phosphate uridylyltransferase (GALT) and UDP-galactose 4'-epimerase (GALE). Additionally GALK2 participates indirectly in the glycolytic pathway by converting galactose derivatives thereby linking carbohydrate metabolism to broader cellular processes like energy generation and cellular respiration.
Abnormalities in GALK2 function or expression have associations with disorders in galactose metabolism such as galactosemia. Galactosemia is a rare condition characterized by the inability to properly metabolize galactose often leading to harmful accumulation of galactose or its derivatives in the body. In addition to this improper GALK2 activity may also relate to certain liver disorders due to disruptions in metabolic processes. In the context of galactosemia GALK2's activity is significant as it connects with enzymes like GALT and GALE which also play roles in this disorder's metabolic pathway.