Abcam, ab153940, Anti-MRPS27 antibody

Size: 100µL
Rabbit Polyclonal MRPS27 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MRPS27 aa 1-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MRPS27 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.Q92552

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MRPS27 also known as Mitochondrial Ribosomal Protein S27 is a protein that plays an essential role in the mitochondrial translation machinery. It is a component of the small mitochondrial ribosomal subunit. MRPS27 has a molecular mass of approximately 23 kDa. This protein is encoded by nuclear DNA and expressed in various tissues with higher levels in tissues having high energy demands like muscle and brain tissues.
Biological function summary
MRPS27 contributes to the formation and function of the mitochondrial ribosome a complex responsible for synthesizing proteins encoded by mitochondrial DNA. It is an integral part of the mitochondrial ribosomal small subunit where it participates in the initiation and elongation phases of mitochondrial protein synthesis. This indicates its importance in maintaining mitochondrial function and cellular energy metabolism.
Pathways
MRPS27 plays a role in the mitochondrial translation pathway where it contributes to the proper synthesis of proteins necessary for the electron transport chain. It interacts with other ribosomal proteins such as MRPS18 and MRPS9 to ensure effective translation processes within mitochondria. These pathways are critical for producing ATP through oxidative phosphorylation a central biochemical process in metabolism.
Defects in MRPS27 have associations with mitochondrial-related diseases including mitochondrial myopathy and encephalopathy. These conditions often arise due to impaired protein synthesis within the mitochondria affecting energy production. Additionally MRPS27 interacts with other proteins like MFN2 which is involved in maintaining mitochondrial network stability and mutations in MFN2 can lead to similar neuromuscular disorders.