Abcam, ab153979, Anti-EML2 antibody

Size: 100µL
Rabbit Polyclonal EML2 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human EML2 aa 200-450.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human EML2 aa 200-450. The exact immunogen used to generate this antibody is proprietary information.O95834

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The EML2 or Echinoderm Microtubule-associated protein Like 2 functions in the regulation of microtubule dynamics. It's a cytosolic protein and can exhibit a molecular weight around 120 kDa. Researchers find EML2 expression in various tissues notably in brain and testes where it likely plays important roles in cellular structure maintenance. This protein shares structural similarities with other members of the EML family highlighting the significance of its conserved WD40 domain.
Biological function summary
EML2 assists in stabilizing microtubules essential for cellular functions such as mitosis and intracellular transport. It is not known to be part of any complex itself but may interact with other proteins involved in microtubule dynamics. EML2 maintains cellular integrity affecting how cells assume shape and move. Mutations or alterations in EML2 can disrupt normal cellular operations indicating its importance for maintaining normal cell physiology.
Pathways
EML2 involves itself in microtubule-related pathways playing a role in cytoskeleton organization. EML2 works in conjunction with tubulin a primary component of microtubules to influence their stability and function. Another associated pathway is the mitotic spindle organization necessary for accurate chromosomal segregation during cell division. EML2 interaction with these pathways suggests it as an important player in cellular division processes.
EML2 links to neurodegenerative disorders and cancers. Alterations in EML2 affect microtubule dynamics which may contribute to diseases such as Alzheimer's where cellular transport and structure become compromised. In cancer deregulation of EML2 can promote uncontrolled cell division. Interactions between EML2 and proteins like Tau in Alzheimer's and EGFR in certain cancers emphasize its relevance to these disease processes making it a target for therapeutic research.