Abcam, ab154068, Anti-FBXO28 antibody

Size: 100µL
Rabbit Polyclonal FBXO28 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human FBXO28 aa 50-350.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human FBXO28 aa 50-350. The exact immunogen used to generate this antibody is proprietary information.Q9NVF7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FBXO28 also known as F-box only protein 28 is an important component of the SCF (Skp1-Cullin-F-box) ubiquitin ligase complex. The molecular mass of FBXO28 is approximately 44 kDa. This protein is expressed in various tissues with noted expression in the brain and heart. As an F-box protein FBXO28 plays an important role in targeting proteins for ubiquitination and subsequent proteasomal degradation.
Biological function summary
FBXO28 functions in regulating cell cycle progression and gene expression. It interacts with specific substrates labeling them for degradation and playing a part in the cell's quality control system. FBXO28 associates as part of the SCF complex which consists of Skp1 Cullin and Rbx1 proteins and helps mediate protein turnover. This protein is key in maintaining cellular homeostasis by eliminating damaged or unneeded proteins.
Pathways
Scientists have identified FBXO28's involvement in the regulation of cell cycle and transcription pathways. It influences the stability of cell cycle regulators linking its activity with the proteasome pathway. FBXO28 also associates with the RNA polymerase II transcription machinery helping control gene expression. Relationships with proteins like CDK1 and Cyclin D mirror its part in cycle control and interactions within transcription pathways highlight its regulatory roles.
Research connects FBXO28 to oncogenic processes particularly in certain cancers due to its regulatory function in cell proliferation. Misregulation of FBXO28 may promote tumor growth revealing its link to cancer pathogenesis. Studies also suggest a possible association with neurological disorders potentially through its expression in brain tissue and interactions with proteins involved in neural pathways raising interest in its broader implications in neurodegenerative diseases.