Abcam, ab154252, Anti-PCBP3 antibody

Size: 100µL
Rabbit Polyclonal PCBP3 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PCBP3 aa 1-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PCBP3 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.P57721

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PCBP3 also known as Poly(rC)-binding protein 3 plays an important role in RNA binding and regulation. This protein has a molecular mass of approximately 38 kDa. PCBP3 gets expressed in many tissues including liver heart and brain suggesting a widespread functional importance. PCBP3 belongs to a family of proteins that includes PCBP1 and PCBP2 all sharing a conserved hnRNP K homology domain involved in nucleic acid binding.
Biological function summary
Poly(rC)-binding proteins like PCBP3 are involved in a variety of cellular processes including mRNA stabilization and translational control. PCBP3 forms part of ribonucleoprotein complexes influencing RNA metabolism and gene expression regulation. Through these interactions PCBP3 contributes to controlling various physiological processes making it a focus of interest in cellular biology research.
Pathways
This protein interacts within important signaling pathways such as those controlling iron homeostasis and RNA processing. PCBP3 connects with proteins like PCBP1 and PCBP2 in pathways modulating iron metabolism influencing both cellular and systemic iron regulation. As part of these pathways PCBP3 maintains functional integrity of cell processes reliant on iron availability and gene expression.
Poly(rC)-binding protein 3 associations include cancer and neurodegenerative diseases. Alterations in PCBP3 expression or function may link to cancer through dysregulated RNA metabolism and cell cycle control. The protein's involvement in iron metabolism also ties it to neurodegenerative diseases where improper iron homeostasis can result in neuronal damage. In these contexts PCBP3 might interact with other RNA binding proteins and iron regulatory proteins highlighting its clinical relevance in disease mechanisms.