Abcam, ab154339, Anti-KRTHA3B antibody

Size: 100µL
Rabbit Polyclonal KRTHA3B antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human, Dog samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human KRT33B aa 100 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Dog,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human KRT33B aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q14525

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: PBS, 20% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
KRTHA3B also known as keratin 83 is a type II hair keratin protein with a molecular mass of approximately 50 kDa. This protein functions mechanically as a structural component in the assembly of intermediate filaments in hair and nail tissues. KRTHA3B forms a critical part of the cytoskeleton in these cells conferring resilience and structural integrity. It expresses prominently in hair follicles and nail beds which is essential for maintaining the strength and rigidity of keratinized tissues.
Biological function summary
Keratins like KRTHA3B are key in building the fibrous framework necessary for tissue stability and function in epithelial cells. KRTHA3B associates with other keratin proteins forming complex networks that are involved in the mechanical support of epithelial cells. Such networks maintain the shape and mechanical resistance required by the cells particularly in the rapidly growing and dividing cells in hair follicles. This protein contributes to filament stabilization ensuring that the structure remains tight and resistant to physical stress.
Pathways
Keratin proteins including KRTHA3B play essential roles in epithelial cell differentiation and structural maintenance. They integrate into pathways such as epithelial-mesenchymal transition (EMT) and cell adhesion playing roles in cellular adhesion dynamics. Related proteins include keratin 19 and keratin 14 which participate together to maintain epithelial cell integrity and function. These pathways ensure structural stability and reliable barrier functions in tissues.
The mutation or deregulation of KRTHA3B can associate with conditions such as hair disorders and some nail dystrophies. Keratin-related disorders often result from dysfunctional filament assembly or structure affecting the affected tissues' resilience. Connected proteins in these disorders include keratin 5 and keratin 17 which are involved in similar filament assembly processes and can contribute to appearance and functionality defects when mutated or expressed incorrectly.