Abcam, ab154531, Anti-KLF3 antibody

Size: 100µL
Rabbit Polyclonal KLF3 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Recombinant Fragment Protein within Human KLF3 aa 150 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human KLF3 aa 150 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P57682

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
KLF3 also known as BKLF (Basic Krüppel-like Factor) is a transcription factor weighing approximately 40 kDa. It regulates gene expression by binding to specific DNA sequences generally influencing various cellular processes. KLF3 is expressed in diverse tissues such as hematopoietic cells and adipose tissues among others. Its presence is observed in both normal physiological conditions and under certain stresses indicating a broader regulatory role.
Biological function summary
KLF3 acts as a major regulator of cell differentiation and proliferation. It functions as part of a transcriptional complex interacting with co-factors to modulate gene networks. Through its zinc finger domains KLF3 binds to DNA and influences the transcription of genes involved in erythropoiesis the process that produces red blood cells and adipogenesis the formation of fat cells. These biological roles suggest that KLF3 maintains homeostasis in tissue development and maturation.
Pathways
Multiple cellular events involve KLF3. It significantly contributes to the TGF-beta signaling pathway and the erythropoiesis pathway. Within these pathways KLF3 interacts with other proteins like TGF-beta receptors and other transcription factors like GATA1. This interaction helps drive transcriptional changes necessary for these pathways' completion indicating KLF3's integral role.
KLF3 plays a part in several conditions including obesity and anemia. In obesity alteration in KLF3 expression affects adipogenesis impacting fat cell formation and accumulation. In anemia KLF3 dysregulation leads to improper erythropoiesis due to its interaction with proteins like GATA1 and EPOR (erythropoietin receptor). These associations underline KLF3's potential implications in managing metabolic and blood disorders.