Abcam, ab154601, Anti-HIPPI/IFT57 antibody

Size: 100µL
Rabbit Polyclonal HIPPI/IFT57 antibody. Suitable for WB, ICC/IF, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human IFT57 aa 200 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human IFT57 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9NWB7

Product details:
Keep as concentrated solution.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HIPPI also known as IFT57 (Intraflagellar Transport Protein 57) is a protein with a mass of approximately 42 kDa. It plays a role in intracellular transport particularly linked to the movement of materials along cilia and flagella. Expression of HIPPI is observed in various tissues notably in neural tissues where it contributes to cellular organization and function. Its involvement in microtubule-based processes highlights its significance in cellular transport mechanisms.
Biological function summary
The protein operates as part of the intraflagellar transport (IFT) complex B functioning in the assembly and maintenance of cilia. HIPPI works closely with other IFT proteins like IFT88 and IFT20 coordinating the movement of protein complexes necessary for ciliary structure and biogenesis. The formation and function of cilia are critical for cellular signaling and movement reflecting HIPPI’s role in supporting these processes.
Pathways
HIPPI integrates into the Hedgehog signaling and Wnt pathways essential for development and cellular differentiation. These pathways involve key proteins like SMO within the Hedgehog pathway and β-catenin in the Wnt pathway linking HIPPI's role in ciliogenesis to broader signaling networks that dictate cell proliferation and patterning. These interactions highlight HIPPI’s participation in major biological pathways that influence cellular communication and development.
HIPPI shows a connection to neurodegenerative conditions and ciliopathies. Evidence links HIPPI to disorders such as Alzheimer’s disease where it interacts with proteins like presenilin influencing neurodegeneration processes. Additionally HIPPI's role in ciliopathies connects it to diseases linked to defects in ciliary function. These associations illustrate HIPPI's involvement in conditions where impaired cellular transport and signaling lead to pathological outcomes.