Abcam, ab154602, Anti-ZAK antibody - N-terminal

Size: 100µL
Rabbit Polyclonal ZAK antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MAP3K20 aa 1-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MAP3K20 aa 1-300. The exact immunogen used to generate this antibody is proprietary information.Q9NYL2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZAK also known as MAP3K20 is a serine/threonine kinase with a molecular mass of approximately 62 kDa. This protein is expressed in various tissues including the heart brain and skeletal muscle. ZAK functions mechanically as an important regulatory kinase acting in signaling cascades that modulate cellular responses to external stress signals. Known for its role in activating downstream MAP kinases ZAK serves as an important part of cellular stress response processes.
Biological function summary
ZAK initiates and participates in the mitogen-activated protein kinase (MAPK) signaling cascade which is integral to cell growth differentiation and apoptosis. ZAK forms part of a signaling complex that transmits signals from the membrane to the cytoplasm. Its activation leads to phosphorylation of other kinases therefore propagating the signal within the cell. Through its role in these signaling pathways ZAK influences cellular processes that maintain homeostasis in response to changing environments.
Pathways
The protein ZAK is deeply involved in the stress-activated protein kinase (SAPK) and JUN amino-terminal kinases (JNK) pathways. These pathways play significant roles in the cell's response to stress signals such as cytokines and environmental stressors. ZAK interacts with and phosphorylates other MAP kinase family members further integrating it into these pathways. Through such interactions ZAK affects related proteins like JNK1 and JNK2 which are essential in mediating stress responses at a cellular level.
ZAK has associations with certain types of cancer and cardiovascular diseases. Its involvement in the MAPK signaling pathway links it to oncogenesis where dysregulation can lead to unchecked cell proliferation. ZAK's interactions with proteins like p38 MAPK play a role in inflammation and stress-response dysregulation contributing to the progression of cancerous growths. In cardiovascular diseases aberrant ZAK activity can lead to issues with heart function and muscle stress responses influencing the pathophysiology of such conditions.