Abcam, ab154612, Anti-TUBA8 antibody

Size: 100µL
Rabbit Polyclonal TUBA8 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TUBA8 aa 1-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TUBA8 aa 1-300. The exact immunogen used to generate this antibody is proprietary information.Q9NY65

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TUBA8 also known as tubulin alpha 8 is a protein involved in maintaining the structure of microtubules. It has a molecular mass of about 50 kDa. This protein serves as an important component of the cytoskeleton helping in cellular shape and intracellular transport. Expression of TUBA8 occurs in various tissues including brain and testes but it is not restricted to these. TUBA8 forms heterodimers with beta-tubulin to construct microtubules playing an essential mechanical role in cell stability and movement.
Biological function summary
TUBA8 contributes to important cellular processes including cell division movement and intracellular transport. It forms part of the microtubule network essential for the dynamic functions of the cytoskeleton. The protein interacts with other tubulin isoforms and various associated proteins facilitating proper cellular function and structure maintenance. By guiding vesicle transport TUBA8 further influences cell signaling and organization.
Pathways
TUBA8 plays an important role in the microtubule assembly pathway and interacts with the mitogen-activated protein kinase (MAPK) pathway. TUBA8's proper functioning is necessary for cellular activities such as mitosis where microtubule dynamics are critical. In the MAPK pathway TUBA8 coordinates with proteins like MAPK1 and MAPK3 impacting cell survival and apoptosis. These interactions show TUBA8's importance in cellular response systems.
Abnormalities in TUBA8 are linked to complex disorders such as lissencephaly and microcephaly. These conditions involve disrupted brain development and abnormal nerve cell positioning highlighting TUBA8's role in neural development. Additionally changes in TUBA8 expression relate to disorders involving the protein LIS1 which also affects microtubule dynamics and brain development. Understanding TUBA8's contribution to these disorders aids in identifying potential therapeutic targets.