Abcam, ab154639, Anti-MIOX antibody

Size: 100µL
Rabbit Polyclonal MIOX antibody. Suitable for IHC-P, WB and reacts with Human, Mouse, Rat samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MIOX aa 1-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MIOX aa 1-250. The exact immunogen used to generate this antibody is proprietary information.Q9UGB7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein MIOX also known as myo-inositol oxygenase plays an important role in the conversion of myo-inositol into D-glucuronic acid. This metabolic enzyme has a mass of about 33 kDa. It is expressed mainly in the kidney particularly in the proximal tubules. MIOX functions as a monomer and contains a non-heme iron at its active site which is essential for its enzymatic activity.
Biological function summary
MIOX is involved in myo-inositol metabolism an important process for maintaining cellular osmolyte balance and signaling. It does not form part of a larger protein complex. Myo-inositol metabolism impacts various cellular functions including phosphoinositide synthesis which is important for cellular signaling pathways. MIOX by controlling myo-inositol levels therefore influences these cellular processes that are critical for kidney function.
Pathways
MIOX is a part of the inositol phosphate metabolism pathway. This pathway is critical for glucose and lipid metabolism affecting energy balance and cellular homeostasis. Additionally MIOX interacts with proteins involved in glucose metabolism such as enzymes in the glycolytic pathway highlighting its role in energy production and regulation. These interactions showcase MIOX's integration in broader metabolic networks.
Abnormal MIOX activity links to conditions such as diabetic nephropathy and kidney injury. MIOX overexpression has been observed in diabetic nephropathy where it might contribute to oxidative stress and kidney damage. Additionally altered MIOX activity associates with proteins like SOD1 which is implicated in oxidative stress responses. Understanding MIOX's involvement offers potential therapeutic insights for managing related renal disorders.