Abcam, ab154640, Anti-ZNF83 antibody - N-terminal

Size: 100µL
Rabbit Polyclonal ZNF83 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ZNF83 aa 1-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ZNF83 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.P51522

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZNF83 also known as Zinc Finger Protein 83 is a protein with a molecular mass of approximately 70 kDa. It functions mechanically as a transcription factor facilitating the binding to specific DNA sequences through its zinc finger motifs. These motifs consist of sequences that enable ZNF83 to interact with DNA and regulate gene expression. The expression of ZNF83 is observed in various tissues with higher levels noted in certain regions of the brain including the cerebral cortex.
Biological function summary
ZNF83 plays a role in modulating gene transcription by binding to DNA influencing the expression of genes involved in multiple cellular processes. ZNF83 does not typically form part of a known multimeric complex but functions independently to regulate specific target genes. By controlling gene expression ZNF83 impacts cell differentiation and development with its activity being integral to normal developmental processes.
Pathways
ZNF83 interacts with gene regulatory networks important in cellular growth and development. Specifically it is associated with the Wnt signaling pathway a critical pathway that controls many aspects of cell fate determination cell migration and organogenesis. Within this pathway ZNF83 may interact with proteins such as β-catenin to exert its influence on gene expression impacting cell proliferation and differentiation.
ZNF83 links to certain neurological conditions due to its expression in the brain and its regulatory functions. Altered ZNF83 activity has been investigated in relation to schizophrenia where it might affect genes important for neuronal function and synaptic plasticity. Furthermore its connection to neurodegenerative disorders has been studied with proteins such as tau and amyloid precursor protein (APP) offering potential links through disrupted signaling pathways highlighting the significance of ZNF83 in neural health.