Abcam, ab154785, Anti-Rho guanine exchange factor 16/NBR antibody [EPR9950]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal Rho guanine exchange factor 16/NBR antibody. Suitable for IHC-P, WB, ICC/IF, Flow Cyt (Intra) and reacts with Human, Mouse samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR9950,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IHC-P, ICC/IF, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Species reactivity
Rat: We have preliminary internal testing data to indicate this antibody may not react with this species.
Please
contact us
for more information.

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Rho guanine exchange factor 16 also known as ARHGEF16 or NBR is a protein that acts as an exchange factor for Rho GTPases by facilitating the exchange of GDP for GTP. This protein has a molecular mass of approximately 100 kDa. It is widely expressed in various tissues with higher levels found in the brain and lungs. The alternative names for this protein "guanine exchange factor" and "anti-ARHGEF16" reflect its involvement in activating small GTPase by swapping GDP with GTP influencing several cellular processes.
Biological function summary
Rho guanine exchange factor 16 plays a role in signal transduction pathways that control cytoskeleton dynamics cell migration and growth. It often functions as part of a larger protein complex involved in cellular response to external stimuli. By interacting with and activating Rho family GTPases like RhoA it contributes to the reorganization of actin filaments and the regulation of cell shape and motility which are critical for tissue remodeling and development.
Pathways
Rho guanine exchange factor 16 participates in pathways such as Rho GTPase cycle and endothelial barrier maintenance. It is closely associated with RhoA within these pathways affecting cell cycle regulation and cellular stress responses. This protein ensures the activation of downstream effectors facilitating changes required for cellular adherence and survival under various physiological conditions.
Dysregulation or mutation of Rho guanine exchange factor 16 links to cancer progression and neurological disorders. Abnormal signaling through this target can lead to altered actin dynamics affecting cell division and migration seen in tumor metastasis. Associated proteins such as RhoA also play roles in these diseases highlighting the complex interaction networks involving Rho guanine exchange factor 16 that can influence disease outcomes.