Abcam, ab154831, Anti-RNF11 antibody [EPR6820]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal RNF11 antibody. Suitable for IHC-P, WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 4 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR6820,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-P, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
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contact us
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Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RNF11 also known as Ring Finger Protein 11 is a ubiquitin ligase that plays a role in the ubiquitination process. It contains a RING finger domain which is important for its function in protein-protein interactions and tagging proteins for degradation. This protein has a molecular mass of approximately 13 kDa. RNF11 is widely expressed in various tissues including the brain heart and liver suggesting its involvement in several cellular processes.
Biological function summary
RNF11 acts as part of the A20 ubiquitin-editing complex which is essential in regulating NF-kB signaling pathways. It interacts with various other proteins to modulate inflammation and immune responses by controlling the degradation of signaling molecules. The presence of RNF11 in immune cells emphasizes its role in immune regulation. RNF11 influences cellular responses to external stress signals thereby maintaining cellular homeostasis.
Pathways
RNF11 plays a significant role in the NF-kB and TGF-beta signaling pathways. It cooperates with proteins such as A20 and ITCH to mediate the ubiquitination process a critical component of these pathways. In the NF-kB pathway RNF11 helps to regulate transcriptional activation which affects inflammation and immune response modulation. Within the TGF-beta pathway it influences cell growth and differentiation.
RNF11 is linked to certain inflammatory diseases and cancers. Malfunction in the regulation by RNF11 can lead to dysregulated NF-kB signaling contributing to chronic inflammatory conditions like rheumatoid arthritis. In cancers altered RNF11 expression levels have been observed potentially affecting tumor growth and metastasis through NF-kB pathway disruption. Its interaction with the deubiquitinating enzyme A20 in these disease states highlights its importance in maintaining normal cellular functions.