Abcam, ab154837, Anti-GBGT1 antibody [EPR10467]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal GBGT1 antibody. Suitable for IHC-P, WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR10467,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-P, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The GBGT1 protein also known as Forssman glycosyltransferase functions as an enzyme involved in the biosynthesis of the Forssman antigen. It is a glycosyltransferase enzyme that adds a specific sugar residue to the terminal position on glyco-conjugates. This enzyme typically weighs around 37 kDa. GBGT1 is expressed in a variety of tissues including the kidney heart and small intestine but its expression varies significantly among different species.
Biological function summary
The Forssman glycosyltransferase enzyme is responsible for the generation of Forssman glycolipids contributing to the structure of cell membranes. These glycolipids play a role in cell-cell interactions. GBGT1 is not typically part of a larger protein complex but acts independently to modify glycolipids affecting cellular communication and recognition processes.
Pathways
GBGT1 is involved in glycosphingolipid biosynthesis pathways specifically influencing the metabolic progression from globoseries to Forssman series glycolipids. This pathway closely interacts with other enzymes like α13-galactosyltransferase which also contributes to glycolipid modification. These enzymes together maintain proper cellular roles involving signaling and interactions at the cell surface.
GBGT1 engagement has been associated with immunological responses and cancer. Aberrant expression or mutation in this enzyme affects antigen presentation which contributes to various cancer types as the presence of Forssman antigen is often noted in tumor tissues. Furthermore it has connections with the α-galactosyltransferase enzyme in xenotransplantation as both are involved in the synthesis of glycolipids that can trigger immune rejection events.