Abcam, ab154868, Anti-Kinesin Heavy Chain 2 antibody [EPR10740(B)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal KIF2A antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR10740(B),
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please
contact us
for more information.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Kinesin Heavy Chain 2 also known as kinesin-2 or KIF3A is a motor protein involved in intracellular transport. It has a molecular mass of about 83 kDa. Kinesin-2 functions by moving along microtubules converting chemical energy from ATP into mechanical work to transport cellular cargo. This protein primarily operates in cellular regions with high microtubule activity such as neurons and epithelial cells. Kinesin-2 is vital for ciliary function as it transports essential components along the axoneme of motile and primary cilia.
Biological function summary
Kinesin-2 operates as part of the kinesin-2 family complex which also includes KIF3B and a kinesin-associated protein (KAP). It manages the anterograde transport of proteins and vesicles necessary for ciliary growth and function. This system is essential for maintaining cilia which play roles in cell signaling and locomotion. Without the proper action of kinesin-2 ciliary assembly and maintenance become impaired leading to compromised cell function.
Pathways
Kinesin-2 is critical in the intraflagellar transport (IFT) pathway and the Hedgehog signaling pathway. In the IFT pathway kinesin-2 works closely with the IFT proteins to shuttle cargo necessary for cilia function from the cell body to the cilia tip. In the Hedgehog pathway kinesin-2 helps transport signaling molecules to cilia which is important for pathway activation. This protein interacts with the IFT-B complex ensuring efficient signal transduction necessary for correct cellular responses.
Kinesin-2 malfunctions associate with ciliopathies and certain types of cancer. Defective kinesin-2 function can cause ciliopathies like Bardet-Biedl syndrome due to its role in ciliary transport. Additionally disruption of kinesin-2-related transport in Hedgehog signaling links to basal cell carcinoma where this signaling pathway often becomes aberrant. These conditions emphasize the importance of kinesin-2 in proper cellular function and its contributions to human health.