Abcam, ab155026, Anti-SNRPB/SmB antibody

Size: 100µL
Rabbit Polyclonal SNRPB/SmB antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 4 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SNRPB also known as SmB is a core component of the spliceosomal small nuclear ribonucleoproteins (snRNPs). It has a molecular weight of approximately 25 kDa. This protein is widely expressed in human tissues especially in those with high proliferative capacity like the brain and immune system. SNRPB plays an essential role in the splicing of pre-mRNA by binding to it and facilitating its processing into mature mRNA.
Biological function summary
SNRPB functions as part of the spliceosome complex which is responsible for removing introns from pre-mRNA. It assists in assembling and stabilizing the snRNPs required for correct splicing. The protein helps ensure cellular pathways operate smoothly by maintaining RNA integrity which is important for gene regulation and expression. SNRPB with other Sm proteins forms a stable core structure needed for snRNP function within the spliceosome complex.
Pathways
Scientists connect SNRPB to the mRNA splicing and gene expression pathways. In particular it interacts closely with other snRNPs like SNRPD1 and SNRPD2 which are also integral to mRNA processing. The accurate function of these proteins within the pathway ensures that cells produce correct protein variants which are essential for cell survival and adaptation to environmental changes.
Researchers often associate SNRPB with spinal muscular atrophy (SMA) and systemic lupus erythematosus (SLE). In SMA dysfunction in snRNP assembly due to mutations in related proteins like SMN1 can lead to motor neuron degeneration. In SLE autoimmune reactions often target snRNPs including SNRPB leading to chronic inflammation and tissue damage. Understanding these associations helps in the exploration of potential therapeutic targets for these challenging diseases.