Abcam, ab155093, Anti-Frizzled 8 antibody [EPR7308(2)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal Frizzled 8 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 9 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR7308(2),
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Epitope:HeLa and Jurkat lysates; Human endometrial carcinoma tissue.,
Specificity:The mouse and rat recommendation is based on the 100% homology with the immunogen. We do not have experimental data in mouse and rat species.

Product details:
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Sold under exclusive licence from Children's Medical Research Institute and Newcastle Innovations Ltd. Rhodadyn™ is a trademark of Children's Medical Research Institute and Newcastle Innovation Ltd.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Frizzled 8 also known as FZD8 forms part of the Frizzled family of proteins which serve as receptors for the Wnt signaling pathway. This protein with a mass of approximately 70 kDa contains a characteristic cysteine-rich domain. FZD8 mainly localizes to the cell membrane and prominently expresses in tissues such as the brain heart and placenta. Its structure includes seven transmembrane domains which contributes significantly to its role in signal transduction.
Biological function summary
FZD8 influences cellular communication within the Wnt signaling pathway impacting processes like cell proliferation and fate determination. FZD8 often associates with other proteins in complex formations particularly when assembling with Wnt ligands on the cell surface. It plays an important role in embryonic development and tissue homeostasis where precise cellular signaling is necessary for maintaining the balance between cell growth and programmed cell death.
Pathways
FZD8 interacts most prominently within the canonical Wnt/β-catenin signaling pathway. It works closely with the Dishevelled (DVL) protein facilitating signal transfer from the cell surface to the cytoplasm and beyond. This involvement tightly links FZD8 to many developmental processes and cellular communication networks. Additionally FZD8 is also implicated in the non-canonical Wnt pathways demonstrating its versatility in various cellular signaling contexts.
FZD8 is associated with conditions such as cancer and neurodegenerative diseases. Dysregulation of FZD8 may contribute to abnormal cell proliferation as observed in certain cancers when improper Wnt signaling causes uncontrolled cellular growth. Additionally its connection with Alzheimer's disease highlights the importance of FZD8 in neuronal maintenance and function. Abberations in FZD8 or its signaling partners such as β-catenin may lead to pathogenesis in these diseases.