Abcam, ab155178, Anti-MK-3 antibody

Size: 100µL
Rabbit Polyclonal MK-3 antibody. Suitable for WB, ICC/IF and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MAPKAPK3 aa 50 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MAPKAPK3 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q16644

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MK-3 also known as MAP kinase-activated protein kinase 3 is a serine/threonine kinase with a mass of approximately 43 kDa. It is widely expressed across various tissues including the brain heart and skeletal muscle. Mechanically MK-3 transduces signals from activated MAP kinases and phosphorylates downstream targets influencing their function and stability. This activity is central to many cellular processes particularly those related to responses to external stimuli.
Biological function summary
MK-3 functions as part of the MAPK signaling cascade and phospho-regulates different substrates that influence cell differentiation and stress responses. The protein interacts within complexes that mediate cellular responses to growth factors and various extracellular signals. MK-3's enzymatic activity modulates pathways involved in inflammation and apoptosis which are essential for maintaining cellular homeostasis and responding to stress.
Pathways
MK-3 plays a significant role in the MAPK and SAPK/JNK pathways. These pathways help regulate responses to environmental stressors and cytokine signaling. MK-3 is closely related to other kinases like p38 MAPK and JNK which collaboratively modulate cellular stress responses. These pathways are important for facilitating communication between extracellular stimuli and intracellular actions.
MK-3 has connections to inflammatory conditions and cancer. Inflammatory diseases such as rheumatoid arthritis involve altered MAPK signaling where MK-3 interacts with proteins such as cytokines that promote inflammation. In cancer aberrant MK-3 activity can support tumor progression by affecting apoptosis and cell cycle regulation linking to proteins like p53 that control cell division and death.