Abcam, ab155495, Anti-SMC6 antibody

Size: 25µL / 100µL
Rabbit Polyclonal SMC6 antibody. Suitable for WB, ICC/IF, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SMC6 aa 500-800.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SMC6 aa 500-800. The exact immunogen used to generate this antibody is proprietary information.Q96SB8

Product details:
Keep as a concentrated solution.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.025% Proclin 300Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SMC6 also known as Structural Maintenance of Chromosomes 6 is a core component of the SMC5/6 complex. It has a molecular mass of about 128 kDa. This protein is expressed in various tissues indicating its widespread role in cellular functions. SMC6 is known for its role in DNA repair and proper chromosome segregation during cell division where it maintains genomic stability.
Biological function summary
SMC6 operates as part of the SMC5/6 complex important for DNA repair processes. The complex is involved in Homologous Recombination Repair (HRR) of DNA double-strand breaks. It also contributes to resolving DNA replication stress. SMC6 ensures that cells sustain genomic integrity by supporting chromosomal dynamics during the cell cycle.
Pathways
The SMC6 protein is significant in DNA damage response and cell cycle checkpoint pathways. It cooperates closely with related proteins like RAD51 and BRCA1. These interactions are essential in maintaining genomic stability aiding in DNA repair and safe replication processes.
Disruption in SMC6 functions relates to cancer and Fanconi anemia. Its role in maintaining DNA integrity associates it with tumor suppression where impaired SMC6 can lead to genomic instability seen in cancers. In Fanconi anemia faulty coordination with other proteins such as FANCD2 affects DNA repair making SMC6 an important target to better understand these conditions.