Abcam, ab155673, Anti-HDHD1A antibody

Size: 100µL
Rabbit Polyclonal HDHD1A antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PUDP aa 1-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PUDP aa 1-200. The exact immunogen used to generate this antibody is proprietary information.Q08623

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HDHD1A also known as haloacid dehalogenase-like hydrolase domain-containing protein 1A serves as an enzyme with phosphatase activity targeting phospho-serine residues. The protein comprises about 24 kDa and is expressed widely in various tissues with notable expression in the brain liver and kidney. Functionally HDHD1A catalyzes the hydrolysis of phosphoserines playing a role in dephosphorylation processes which is a critical aspect of cellular signaling and regulation.
Biological function summary
HDHD1A plays an essential role in regulating serine phosphorylation status within cells affecting multiple signaling pathways and cellular functions. Although HDHD1A does not form part of larger protein complexes its activity influences the phosphorylation landscape facilitating protein-protein interactions and modulating downstream effects. This regulatory ability helps maintain phosphorylation equilibrium arguably impacting cell growth and division processes.
Pathways
HDHD1A becomes involved in cellular signal transduction and metabolic pathways by modulating protein phosphorylation states. One significant pathway includes the MAPK (mitogen-activated protein kinase) signaling cascade which profoundly influences cell proliferation differentiation and apoptosis. Within these pathways proteins like ERK (extracellular signal-regulated kinase) and MEK (MAPK/ERK kinase) could relate closely to HDHD1A's activity affecting overall pathway dynamics and cellular responses.
HDHD1A associates with neurological and metabolic conditions due to its regulatory role in phosphorylation. Aberrant HDHD1A activity may connect to Alzheimer's disease potentially through dysregulated MAPK signaling influencing protein networks involving tau and amyloid precursors. Furthermore links to metabolic disorders arise as HDHD1A might affect glycerolipid metabolism implicating conditions such as obesity when interacting with proteins like insulin receptor substrates.