Abcam, ab155781, Anti-RPL17 antibody

Size: 100µL
Rabbit Polyclonal RPL17 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Rat, Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human RPL17 aa 1 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human RPL17 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P18621

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RPL17 also known as Ribosomal Protein L17 is an essential component of the ribosome the cellular machinery responsible for protein synthesis. It is encoded by the RPL17 gene and its protein product has a mass of approximately 21 kDa. Expressed in various tissues RPL17 shows high levels in cells with active protein production needs including in liver kidney and heart tissues.
Biological function summary
RPL17 acts as a part of the ribosomal 60S subunit playing a role in assembling and stabilizing the ribosome structure. It interacts closely with other ribosomal proteins and ribosomal RNA (rRNA) to facilitate efficient protein translation. As a structural constituent of the ribosome it does not work in isolation but as part of a larger complex necessary for mRNA translation into polypeptides.
Pathways
The protein RPL17 is involved in the translation pathway and ribosome biogenesis. These pathways are important for gene expression. Within the translation pathway RPL17 interacts with multiple ribosomal proteins such as RPL5 and RPL10 to ensure accurate decoding of mRNA. The protein's integration aids in the assembly and function of the ribosome which impacts overall cellular function and growth.
Alterations or defects in the expression of RPL17 have been linked to ribosomopathies which are disorders characterized by defective ribosome function. For example Diamond-Blackfan anemia involves mutations in ribosomal proteins including RPL17 which disrupt normal erythropoiesis. Additionally RPL17 may interact with tumor suppressor proteins like p53 implicating it in pathways related to cancer development and progression. Understanding these connections furthers insights into the molecular basis of these conditions.