Abcam, ab157090, Anti-NUP205 antibody

Size: 100µg
Rabbit Polyclonal NUP205 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human NUP205 aa 1750-1800.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human NUP205 aa 1750-1800. The exact immunogen used to generate this antibody is proprietary information.Q92621

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab157090 was affinity purified using an epitope specific to NUP205 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Avoid freeze / thaw cycle, Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein NUP205 also known as nucleoporin 205 kDa is an important structural component of the nuclear pore complex (NPC). It has a molecular mass of approximately 205 kDa. NUP205 is expressed ubiquitously in eukaryotic cells as part of the nuclear envelope where it is an essential link in regulating the transport of molecules between the nucleus and the cytoplasm. The expression patterns show its presence across different cell types indicating its fundamental role in cellular function.
Biological function summary
NUP205 is an essential component of the nuclear pore complex contributing to nuclear-cytoplasmic transport. The protein works in concert with other nucleoporins to form the scaffold of the NPC facilitating the bidirectional movement of proteins and RNA. NUP205 as part of this large multiprotein complex plays a significant role in maintaining cellular compartmentalization and influencing gene expression patterns by controlling the transit of regulatory molecules in and out of the nucleus.
Pathways
NUP205 interacts significantly within the nuclear transport pathway. It engages intimately in the regulation of protein and RNA shuttling which influences gene expression and cell cycle processes. NUP205 associates with other nucleoporins such as NUP214 and NUP62 participating in processes like signal transduction and RNA processing. Its functionality supports broader cellular pathways by acting as a gatekeeper ensuring essential factors access or exit the nucleus as needed.
NUP205 has connections to various pathological conditions stemming from disrupted nucleocytoplasmic transport. It is implicated in acute myeloid leukemia (AML) where aberrant expression or mutations of NUP205 can disrupt normal cellular transport functions possibly in association with NUP214. Additionally defects in NUP205 function have been linked to certain neurodegenerative conditions highlighting its role in maintaining neuronal cell homeostasis. Understanding NUP205's molecular behavior offers potential insights into the pathogenesis of these diseases and targets for therapeutic intervention.