Abcam, ab157480, Anti-HBXIP antibody [EPR11531(B)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal HBXIP antibody. Suitable for WB, Flow Cyt (Intra) and reacts with Human, Mouse, Rat samples. Cited in 6 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR11531(B),
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb
patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HBXIP also known as Hepatitis B X-interacting protein or LAMTOR5 is a protein with a mass of approximately 18 kDa. HBXIP binds to the HIV-1 protease and is involved in the activation of diverse cellular processes. It predominantly expresses in heart kidney liver and skeletal muscle tissues. The protein's mechanical role involves interacting with the hepatitis B virus X protein (HBx) enhancing the replication of hepatitis B virus particles.
Biological function summary
HBXIP impacts multiple cellular functions in a complex manner. It participates in the regulation of centrosome dynamics and cell division. HBXIP interacts with proteins such as survivin in a complex that plays a role in mitosis. HBXIP also influences gene expression by modulating estrogen receptor signaling. These functions make HBXIP a significant component in cellular growth control.
Pathways
HBXIP engages in cell cycle regulation and apoptosis. It affects the mTOR signaling pathway important for cell growth and metabolism. Within this context HBXIP acts alongside proteins like mTOR and RHEB influencing nutrient and energy status in the cell. Furthermore its interaction with the p53 pathway highlights its role in controlling cell survival and the response to DNA damage.
HBXIP displays connections to cancer and viral infections. In cancer HBXIP overexpression correlates with tumor progression and poor patient prognosis commonly seen in breast cancer. Through its influence on nuclear factor-kB (NF-kB) HBXIP associates with inflammatory responses tied to cancer progression. Additionally its relationship with hepatitis B viral oncogenesis highlights a link between HBXIP and liver disorders signaling interaction with the viral HBx protein as a point of mechanism.