Abcam, ab157919, Recombinant Human ASIP protein

Size: 10µg
Recombinant Human ASIP protein is a Human Fragment protein, in the 33 to 132 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:P42127,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The agouti signaling protein (ASIP) also known as agouti protein or agouti switch protein functions mechanically as an antagonist to the melanocortin 1 receptor (MC1R). This interaction influences pigmentation processes by modulating eumelanin and pheomelanin production. ASIP possesses a mass of approximately 14 kDa. It is expressed in several tissues such as skin adipose tissue and neural tissues highlighting its varied roles in different biological contexts.
Biological function summary
ASIP plays an important role in pigmentation regulation and energy homeostasis. It prevents MC1R from binding its ligand alpha-melanocyte-stimulating hormone (α-MSH) leading to lightening of skin and fur coloration by shifting melanin production from eumelanin to pheomelanin. Although ASIP is not part of a larger protein complex its interaction with the MC1R receptor greatly influences pigmentation phenotypes.
Pathways
ASIP integrates into the melanocortin signaling pathway which regulates skin and hair color as well as energy expenditure. It interacts with key pathway proteins such as MC1R and α-MSH driving the balance between pigmentation and metabolic activity. ASIP’s role extends to pathways related to lipid metabolism linking it to proteins involved in energy balance and adiposity.
ASIP shows association with conditions such as obesity and melanoma. Its influence on energy homeostasis implicates it in the development of obesity where altered ASIP expression affects lipid storage and metabolism. ASIP’s interaction with MC1R also ties it to melanoma risk as changes in its activity might predispose individuals to pigmentation disorders influencing melanoma susceptibility. These interactions showcase ASIP’s connection to disease states through its modulation of receptor-related functions.