Abcam, ab158567, Recombinant Human GPCR GPR31 protein

Size: 10µg
Recombinant Human GPCR GPR31 protein is a Human Full Length protein, in the 1 to 319 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:O00270,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GPR31 also known as G protein-coupled receptor 31 is a member of the GPCR family. This receptor has a mass of approximately 35 kDa. It is widely expressed in human tissues with notable expression in the brain liver and immune cells. GPR31 plays a significant role in transmitting extracellular signals through the cell membrane activating intracellular G proteins and triggering various signaling pathways.
Biological function summary
GPR31 influences cellular processes such as growth and response to environmental changes. It does not associate with a specific complex but interacts with several intracellular signaling molecules. Its function in immune cells suggests a role in immunoregulation and inflammation. Additionally GPR31 might have effects on cell proliferation and migration especially in liver and cancer cells.
Pathways
GPR31 directly influences the arachidonic acid and leukotriene B4 signaling pathways. These pathways regulate inflammation and immune responses. GPR31 interacts with specific proteins like GPR120 and CB2 receptors. Its role within these pathways suggests potential implications in inflammatory diseases and conditions linked to overactive immune responses.
GPR31 has significant relevance to liver cancer and inflammatory bowel disease. Research links GPR31 to the progression of liver cancer by affecting cancer cell proliferation and migration. It also plays a role in the dysregulation of inflammatory responses in bowel diseases via its interaction with CB2 receptors and pathways influenced by inflammation.