Abcam, ab158861, Recombinant Human MAS1 protein

Size: 2µg
Recombinant Human MAS1 protein is a Human Full Length protein, in the 1 to 325 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:P04201,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MAS1 also known as MAS-1 or anti-MAS is a G protein-coupled receptor (GPCR) with a molecular mass of about 37 kDa. It exists in various tissues including the brain heart kidneys and blood vessels. As a receptor MAS1 binds to its ligand to activate intracellular signaling. This receptor's presence in multiple organs highlights its importance in various physiological functions and systems.
Biological function summary
MAS1 functions as a component of the renin-angiotensin system (RAS) where it counteracts the effects often seen with angiotensin II binding to AT1 receptors. It acts as a receptor associated with the signaling of angiotensin-(1-7) a peptide known for vasodilatory and anti-proliferative effects. This receptor is not only a single unit but also participates in forming complexes with other receptor proteins to execute its functions effectively.
Pathways
This receptor engages in the angiotensin-(1-7)/MAS axis a branch of the RAS. This axis balances the actions of the classical angiotensin II/AT1 receptor pathway. Its signaling typically includes pathways involving nitric oxide release and kinases like PI3K and Akt impacting vasodilation and cellular growth inhibition. MAS1 has functional links to proteins like AT1 and AT2 receptors which are also critical components of the RAS.
MAS1 plays a role in conditions like hypertension and heart failure. Its interaction with angiotensin-(1-7) highlights its role in counteracting the CVD-promoting effects of angiotensin II. Moreover in disorders like hypertension MAS1's counter-regulatory function becomes significant highlighting its potential therapeutic value. The target’s modulatory effect on the RAS makes it a relevant protein in cardiovascular research alongside AT1 receptors due to their combined effect on blood pressure regulation and cardiac function.