Abcam, ab159415, Recombinant Human RPL36A protein

Size: 10µg
Recombinant Human RPL36A protein is a Human Full Length protein, in the 1 to 106 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:P83881,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RPL36A also known as Ribosomal Protein L36-A or L36A is a component of the 60S ribosomal subunit. This protein has a mass of approximately 12 kDa and is widely expressed in various tissues mainly reflecting its fundamental role in cellular processes. As an essential part of the ribosome RPL36A helps facilitate the translation of messenger RNA into proteins contributing to the protein synthesis machinery which is essential for cell function and proliferation.
Biological function summary
RPL36A is involved in the ribosome's structural integrity and function. It assumes an important role within the ribosomal large subunit by engaging in ribosome assembly and stability. As a part of the ribosomal complex RPL36A contributes to the decoding and translocation phases during protein biosynthesis. Its integration within this complex highlights its significance in cellular metabolism and growth.
Pathways
RPL36A plays an integral part in the translation pathway specifically in the process of translation initiation and elongation. It is actively involved in the assembly of the pre-initiation complex and the elongation cycle. Additionally RPL36A interacts within the mTOR signaling pathway which regulates cell growth and metabolism in response to nutrients growth factors and other stimuli. Through this pathway its relationship with proteins like S6 kinase is noteworthy as they collectively influence protein synthesis rate and cell growth.
Alterations in RPL36A can potentially relate to cancer and Diamond-Blackfan anemia (DBA). Changes in the expression levels or mutations of RPL36A have been implicated in the development of certain cancers where enhanced ribosomal biogenesis supports tumor growth. In DBA a disorder characterized by failure in red blood cell production mutations in ribosomal proteins like RPL36A disrupt ribosome function leading to hematological abnormalities. Interactions with other ribosomal proteins such as RPS19 further illustrate its involvement in the pathogenesis of ribosomopathies.