Abcam, ab159659, Recombinant Human TCR V delta 1 protein

Size: 10µg
Recombinant Human TCR V delta 1 protein is a Human Fragment protein, in the 173 to 272 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:B7Z8K6,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The TCR V delta 1 or T-cell receptor Vδ1 is a subunit of the gamma-delta T-cell receptor complex. This protein is important in recognizing antigens that are not processed and presented by MHC complexes. TCR V delta 1 weighs around 60 kDa and is mainly expressed on a subset of gamma-delta T cells primarily in mucosal tissues like the skin intestines and lungs. These locations allow it to participate in immune surveillance and responses against pathogens and cancer cells.
Biological function summary
TCR V delta 1 is integral to the function of gamma-delta T cells which play a unique role in the immune response by recognizing stressed cells and presenting non-peptide antigens. Unlike alpha-beta T cells gamma-delta T cells often involving TCR V delta 1 do not require antigen presentation via MHC molecules. Therefore they can respond faster to certain pathological conditions. TCR V delta 1 pairs with the gamma chain in the receptor complex influencing the activation and proliferation of these T cells and modulating immune responses.
Pathways
TCR V delta 1 participates in key immune processes such as the recognition of phosphoantigens and stress-induced ligands through pathways like the Vδ1 T cell activation pathway and TCR signaling. The protein works closely with signaling molecules like CD3 and proteins in the MAPK pathway which together regulate gamma-delta T cell activation survival and cytokine production. Through these pathways TCR V delta 1 contributes to antitumor immunity and the maintenance of tissue homeostasis.
TCR V delta 1 shows relevance in various conditions including cancer and autoimmune diseases. In some cancers like melanoma Vδ1 T cells through mechanisms related to TCR V delta 1 show potential in targeting and eliminating tumor cells. In autoimmune conditions such as celiac disease aberrant gamma-delta T cell responses can occur with TCR V delta 1 influencing the pathogenesis. Additionally interactions with proteins like NKG2D can influence these disease processes affecting how gamma-delta T cells either protect or exacerbate disease states.