Abcam, ab160325, Recombinant Human Claudin 12 protein

Size: 10µg
Recombinant Human Claudin 12 protein is a Human Full Length protein, in the 1 to 244 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:P56749,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Claudin 12 is a component of the tight junction proteins sometimes referred to as CLDN12. It is a small protein with a molecular mass approximately of 24 kDa. Claudin 12 is expressed particularly in epithelial tissues including the intestine and kidney where it contributes to the formation of tight junction strands. These strands regulate the paracellular transport and Claudin 12's specific role involves modulating permeability to ions and small molecules in these tissues.
Biological function summary
The protein Claudin 12 acts to maintain barrier functions in epithelial layers. As a member of the claudin family it participates in creating a selective permittivity barrier in the tight junction complex. This complex is essential for maintaining the separation between different bodily compartments and regulating the passage of various substances. Claudin 12 assists in preserving the ion balance and protecting tissue integrity against external factors.
Pathways
The protein Claudin 12 plays important roles in cellular signaling and homeostasis. It is involved in the tight junction signaling pathway where it interacts with other claudins such as Claudin 1 and Claudin 4. The protein contributes to the epithelial-to-mesenchymal transition (EMT) pathway impacting cellular adhesion and movement. These interactions allow cells to respond to changes in the environment supporting processes such as development and tissue repair.
Claudin 12 holds connections to various health conditions. Alterations in Claudin 12 expression and function are linked to disorders such as inflammatory bowel disease and cancer. In these conditions its relationship with Claudin 3 and occludin may influence barrier integrity and immune response. Understanding Claudin 12's role in disease can improve insights into epithelial-layer related disruptions and inform therapeutic strategies.