Abcam, ab160463, Recombinant Human Neurexin 1 protein

Size: 10µg
Recombinant Human Neurexin 1 protein is a Human Fragment protein, in the 31 to 130 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q9ULB1,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Neurexin 1 is a synaptic adhesion molecule involved in the formation and maintenance of synapses. Commonly referred to as NRXN1 this protein exists as part of the larger neurexin family which includes neurexin 1 alpha. Neurexin 1 has a molecular weight of approximately 190 kDa and shows expression in neurons of the central nervous system contributing to communication between neurons by stabilizing the synaptic junctions. It acts as a bridge between presynaptic and postsynaptic cells facilitating efficient signal transmission.
Biological function summary
Neurexin 1 participates in the assembly of trans-synaptic signaling complexes. It forms complexes with neuroligins which are postsynaptic cell adhesion proteins impacting synaptic specificity and connectivity. Through its interactions Neurexin 1 helps organize and regulate synaptic transmission influencing the efficiency and plasticity of synaptic connections. These processes are important for proper brain function impacting learning and memory retention.
Pathways
Neurexin 1 plays significant parts in neurotransmitter release mechanisms. It is involved in synaptic vesicle exocytosis pathway where it interacts with the presynaptic active zone components to influence neurotransmitter release. Additionally Neurexin 1 is linked to the glutamatergic synapse pathway where it interacts with neuroligins to modulate excitatory synaptic strength. These interactions ensure the balance of excitatory and inhibitory signals within neural networks.
Neurexin 1 has connections to autism spectrum disorders and schizophrenia. Alterations in Neurexin 1 gene have been associated with synaptic dysfunctions observed in these conditions. Studies suggest that mutations within the NRXN1 gene can disrupt normal synaptic activity contributing to the pathophysiology of these neurodevelopmental and psychiatric disorders. Neurexin 1 also interacts with neuroligins and SHANK3 both implicated in autism and schizophrenia establishing a further link between synaptic stabilization and disease manifestations.