Abcam, ab16126, Anti-EBNA 3A antibody

Size: 250µg
Sheep Polyclonal EBNA3 antibody. Suitable for WB, ICC, Dot, ELISA, IHC-Fr and reacts with Epstein-Barr virus samples. Cited in 16 publications.
Key facts
Host species:Sheep,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Epstein-Barr virus,
Applications:WB, Dot, IHC-Fr, ELISA, ICCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Specificity:This antibody is specific for the Epstein Barr Virus Nuclear Antigen 3A.

Product details:
Sheep were immunized with recombinant EBNA-3A protein

Properties and Storage Information:
Form-Liquid, Purification technique-Precipitation Ammonium Sulphate, Purification notes-Purified by ammonium sulfate precipitation.This antibody is provided as a 0.2µm sterile filtered solution., Storage buffer-Preservative: 0.08% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
EBNA 3A also known as Epstein-Barr Nuclear Antigen 3A is a protein associated with the Epstein-Barr virus (EBV). This protein has a mass of approximately 115 kDa and is expressed in host cells infected with EBV. EBNA 3A functions as a transcriptional regulator by interacting with DNA and modulating gene expression. EBNA 3A is critical for viral latency and is expressed within the nuclei of infected B lymphocytes contributing to the persistence of the virus within host cells.
Biological function summary
EBNA 3A modulates the host cell cycle and contributes to the immortalization of infected B cells. EBNA 3A EBNA 3B and EBNA 3C form a complex that regulates viral and cellular genes. This complex plays roles in transcriptional repression and activation affecting cell growth and transformation. Through these mechanisms EBNA 3A influences immune evasion by the virus as EBV can maintain a state of latency and avoid detection by the host immune system.
Pathways
EBNA 3A participates in the regulation of the cell cycle and immune signaling. EBNA 3A affects pathways such as the Notch signaling pathway and can alter interactions with proteins like RBP-Jκ. These pathways are important for the control of gene expression and cell differentiation in infected cells. By influencing these pathways EBNA 3A helps EBV manipulate host cell behaviors to support viral replication and persistence.
EBNA 3A is linked to conditions like Burkitt's lymphoma and Hodgkin's lymphoma. These cancers are associated with the transformation of B cells resulting from EBV infection and EBNA 3A collaborates with other viral proteins such as EBNA-LP to contribute to the oncogenic processes. The presence and activity of EBNA 3A in these lymphomas suggest that targeting this protein could offer potential therapeutic avenues for managing EBV-related malignancies.