Abcam, ab161292, Recombinant Human ADAMTS8 protein

Size: 10µg
Recombinant Human ADAMTS8 protein is a Human Fragment protein, in the 781 to 890 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q9UP79,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The ADAMTS8 protein also known as A Disintegrin and Metalloproteinase with Thrombospondin Motifs 8 functions mechanically as a metalloproteinase enzyme involved in the modulation of the extracellular matrix. It has a molecular mass of approximately 137 kDa. ADAMTS8 is expressed in various human tissues including lung and brain with a noted expression in vascular tissues. Through its enzymatic activity it plays an important role in tissue remodeling and proteolytic processing of other proteins.
Biological function summary
The function of this proteolytic enzyme extends to regulating components of the extracellular matrix and aiding in processes such as organ development and response to injury. ADAMTS8 does not typically form part of larger protein complexes but interacts closely with substrates in the extracellular matrix. Its activity impacts the integrity and flexibility of tissues by cleaving protein components such as versican.
Pathways
ADAMTS8 influences specific signaling processes particularly within the extracellular matrix organization pathway and metabolism of proteins. It associates with proteins such as aggrecan and decorin through its degradation roles. By modulating these pathways ADAMTS8 is critical in maintaining the dynamics of matrix turnover and influencing cell-matrix interactions.
ADAMTS8 has relevance in cancer and cardiovascular diseases. Its altered expression or dysfunction can contribute to tumor development and progression by affecting the tumor microenvironment. Related proteins such as ADAMTS1 and ADAMTS5 also engage in similar pathways and processes highlighting their collective involvement in disease processes. Similarly dysregulation of ADAMTS8 can impact vascular conditions linking it to pathogenesis in cardiovascular abnormalities.