Abcam, ab161432, Recombinant Human ATF5 protein

Size: 2µg
Recombinant Human ATF5 protein is a Human Full Length protein, in the 1 to 282 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q9Y2D1,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ATF5 also known as Activating Transcription Factor 5 weighs about 37 kDa and is mainly expressed in the brain and testis. This transcription factor belongs to the ATF/CREB family. It regulates gene expression by binding to cAMP-responsive elements (CRE) on DNA. Unlike other members of its family ATF5 mainly shows regulatory roles under stress conditions influencing cellular responses and survival.
Biological function summary
ATF5 impacts various cellular processes including differentiation apoptosis and cellular stress responses. It functions as a monomer and does not typically form part of any large protein complex. In neuronal cells ATF5 helps sustain neuron survival while in other cells it modulates cell differentiation signals. The expression and activity of ATF5 adjust during development and in response to cellular stress indicating its significant role in cell fate decisions.
Pathways
ATF5 plays key roles in the cellular stress response and metabolic regulation pathways. It links to the endoplasmic reticulum (ER) stress pathway where it aligns with proteins like ATF4 and CHOP to mediate stress-induced apoptosis. Additionally in metabolic pathways ATF5 interacts with PGC-1 alpha to regulate metabolic processes. These interactions highlight ATF5's role in adjusting cellular function according to metabolic needs and stress conditions.
Alterations in ATF5 expression relate to cancer and neurodegenerative disorders. For instance in glioblastoma ATF5 upregulation promotes tumor cell survival and proliferation. It also connects with proteins such as HIF-1 alpha linking it to hypoxia adaptation in tumor cells. In neurodegenerative diseases like Alzheimer’s the role of ATF5 in cell survival pathways becomes significant especially considering its cooperation with proteins involved in stress responses.