Abcam, ab161641, Recombinant Human GPR161 protein

Size: 10µg
Recombinant Human GPR161 protein is a Human Fragment protein, in the 362 to 460 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q8N6U8,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GPR161 also known as G protein-coupled receptor 161 is a large transmembrane protein with a molecular weight of approximately 121 kDa. It belongs to the family of G protein-coupled receptors (GPCRs) and is mainly expressed in cilia of various cell types especially in the neural tube and limb buds during development. This receptor engages in the modulation of intracellular signaling pathways by sensing extracellular molecules.
Biological function summary
GPR161 functions as a negative regulator of the hedgehog (Hh) signaling pathway. It does so by promoting the degradation of GLI transcription factors in the absence of hedgehog ligands. GPR161 integrates within the ciliary membrane compartment playing an important role in maintaining proper cellular response to Hedgehog pathway signals. Its activity ensures balanced cellular growth and differentiation critical during embryonic development.
Pathways
GPR161 acts significantly within the hedgehog signaling pathway and the primary cilia-related signaling processes. It correlates with other proteins like Patched1 and Smoothened which are essential in Hh signaling cascade. GPR161’s regulation of the pathway involves key interactions that control cellular proliferation and tissue polarity.
GPR161 has a connection with developmental disorders and certain cancers. Altered expression or mutations in GPR161 may lead to neural tube defects due to disrupted Hedgehog signaling. Moreover aberrant activity of this receptor relates to basal cell carcinoma where its association with Glioblastoma-associated oncogene family zinc finger proteins plays a role in tumor progression and proliferation.