Abcam, ab162170, Recombinant Human TRBV5-4 protein

Size: 10µg
Recombinant Human TRBV5-4 protein is a Full Length protein, in the 1 to 308 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Animal free:No,
Carrier free:No,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The TRBV5-4 also known as T-cell receptor beta variable 5-4 is a part of the T-cell receptor complex. It contributes to the antigen recognition and immune response function. This protein has a predicted molecular weight of around 13 kDa. TRBV5-4 is expressed in T-cells which are an important component of the adaptive immune system. Understanding the mechanical function of TRBV5-4 is important to elucidate how T-cells identify and respond to pathogens or other foreign substances.
Biological function summary
TRBV5-4 interacts with other segments of the T-cell receptor complex to mediate T-cell specificity and response. It plays a role in recognizing peptide antigens presented by Major Histocompatibility Complex (MHC) molecules on antigen-presenting cells. The process of antigen recognition is fundamental for initiating T-cell-mediated immune responses. By doing so TRBV5-4 contributes to the adaptive immune system's ability to distinguish between self and non-self molecules and mount appropriate immune responses.
Pathways
The TRBV5-4's involvement is mainly in the T-cell receptor signaling pathway and the immune synapse formation. It serves as an important component in ensuring T-cell activation upon recognition of the antigen-MHC complex. The pathway involves interaction with several proteins including CD3 and ZAP70 which transduce the activation signal inside the T-cell. These interactions are important for successful signal propagation necessary for subsequent immune responses.
Mutations or alterations in TRBV5-4 expression can be associated with immune system-related conditions such as autoimmune diseases and certain types of cancer. For example its aberrant activity might contribute to the pathogenesis of autoimmune disorders by inappropriate T-cell activation. Additionally TRBV5-4 might link with proteins like the MHC molecules in influencing immune escape mechanisms in cancerous cells. Understanding such associations helps in exploring TRBV5-4 as a potential therapeutic target in these disorders.