Abcam, ab162283, Recombinant Human OSGIN1 protein

Size: 10µg
Recombinant Human OSGIN1 protein is a Human Full Length protein, in the 1 to 477 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q9UJX0,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The OSGIN1 gene also known as Oxidative Stress Induced Growth Inhibitor 1 encodes a protein that weighs approximately 56 kDa. This protein plays an important role in cellular response to oxidative stress. It is expressed in various tissues including the liver kidney and brain. The OSGIN1 protein functions by inducing apoptosis when oxidative stress is detected aiding the cell in managing damage from reactive oxygen species.
Biological function summary
The ability of OSGIN1 to regulate cell death allows it to maintain cellular homeostasis. This protein does not operate as part of a complex but performs its functions by altering the transcription of specific genes involved in cell growth and death. By modulating genes linked to oxidative damage OSGIN1 controls balance between cell survival and apoptosis thereby influencing cell fate in stressful environments.
Pathways
OSGIN1 plays a significant role in the oxidative stress response pathway by interacting with key proteins such as p53 and Nrf2. These interactions facilitate the antioxidant responses of cells. By promoting p53-mediated apoptosis and Nrf2-related antioxidant gene expression OSGIN1 helps in protecting cells from oxidative damage contributing to the proper functioning of related pathways.
The dysregulation of OSGIN1 is associated with conditions like cancer and neurodegenerative diseases. Aberrant expression of OSGIN1 can lead to either excessive cell death or survival contributing to tumorigenesis in various cancers. Additionally in neurodegenerative disorders OSGIN1 dysfunction can disrupt neuronal survival. The protein connects with dysregulated p53 activity in cancer and Nrf2 pathway alterations in neurodegenerative diseases influencing disease progression.