Abcam, ab162445, Recombinant Human epsilon Tubulin protein

Size: 10µg
Recombinant Human epsilon Tubulin protein is a Human Full Length protein, in the 1 to 475 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q9UJT0,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Epsilon tubulin also known as TUBE1 is part of the tubulin family of proteins involved in microtubule formation. It has a molecular mass of approximately 55 kDa. Epsilon tubulin localizes primarily to centrioles structures located at the core of centrosomes the key organizers of microtubules in cells. Epsilon tubulin expression occurs in tissues with high cell division activity such as in embryonic and tumor cells where centriole replication is essential.
Biological function summary
Epsilon tubulin plays a role in the assembly and stabilization of microtubules. It is part of the centriolar complex which is involved in the nucleation and anchoring of microtubules at the centrosome. This function is important for maintaining cell polarity motility and intracellular transport. During cell division epsilon tubulin assists in forming the mitotic spindle ensuring chromosomes are properly segregated.
Pathways
Microtubule dynamics and organization involve epsilon tubulin as an integral part of centrosome maturation and spindle assembly pathways. It interacts with other tubulin isotypes like alpha and beta tubulin to facilitate the polymerization of tubulin dimers essential for microtubule stability and growth. Epsilon tubulin's function connects to the regulatory systems controlling cell cycle progression ensuring proper cell division and the prevention of aneuploidy.
Abnormalities in epsilon tubulin expression or function relate to conditions such as cancer and ciliopathies. In cancer disrupted microtubule dynamics and spindle assembly may involve epsilon tubulin dysregulation leading to genomic instability and tumor progression. Similarly its altered function could connect with disorders involving the primary cilium such as polycystic kidney disease where defective microtubule anchoring and centrosome function play a role.