Abcam, ab162684, Recombinant Human UBASH3A protein

Size: 10µg
Recombinant Human UBASH3A protein is a Human Full Length protein, in the 1 to 451 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:P57075,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
UBASH3A also known as suppressor of T-cell receptor signaling 1 (STS-1) is a protein involved in regulating T-cell signaling. It has a molecular mass of approximately 67 kDa. UBASH3A is expressed mainly in lymphoid tissues including the thymus and spleen. The protein contains a Src homology 3 (SH3) domain and a ubiquitin-associated (UBA) domain which are important for its interactions with other proteins and its function in cellular signaling processes.
Biological function summary
UBASH3A plays an important role in modulating immune responses. It regulates T-cell receptor (TCR) signaling by acting as a negative regulator ensuring proper immune tolerance and preventing overstimulation of immune responses. UBASH3A is not known to be part of a larger protein complex. It interacts with signaling molecules and adaptor proteins to modulate signal transduction pathways in T-cells controlling their activation and proliferation.
Pathways
UBASH3A influences T-cell signaling pathways and the broader immune response. It is involved in the TCR signaling pathway which is essential for the activation and development of T-cells. Through this pathway UBASH3A interacts with proteins like LCK and ZAP-70 which are necessary for TCR-induced signaling events leading to cytokine production and cell-mediated immune responses. Additionally UBASH3A is connected to pathways controlling apoptosis where it fine-tunes the balance between cell survival and programmed cell death.
UBASH3A has implications in autoimmune diseases and cancer. Its role as a negative regulator of TCR signaling links it to autoimmune conditions such as type 1 diabetes where improper TCR signaling can lead to autoimmune attack of pancreatic beta cells. Furthermore altered expression or function of UBASH3A can impact cancer progression particularly in hematological cancers like leukemia where T-cell signaling dysregulation can promote proliferation. Proteins such as CTLA-4 and PD-1 which are involved in immune checkpoint pathways can be indirectly influenced by UBASH3A activity affecting disease progression and treatment outcomes.