Abcam, ab162734, Recombinant Human SIAE protein

Size: 10µg
Recombinant Human SIAE protein is a Human Full Length protein, in the 1 to 523 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q9HAT2,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Sialic acid acetylesterase also known as SIAE is an enzyme that functions by removing acetyl groups from sialic acids on glycoconjugates. This enzyme belongs to the esterase family and exhibits a mass of approximately 60 kDa. SIAE shows expression in various tissues including the liver kidney and brain. It operates by breaking these acetyl linkages which is an important step in regulating sialic acid biology.
Biological function summary
SIAE modifies the sialylation of glycoconjugates which impacts cellular recognition and communication. This enzyme is part of the immune regulation complex influencing how immune cells recognize and interact with each other as well as their environment. SIAE’s activity can alter cell surface properties which affects processes such as cell adhesion migration and signaling.
Pathways
This enzyme appears in sialic acid metabolic pathways and immune response pathways. Within the context of the sialic acid metabolism pathway it works collaboratively with other enzymes like NEU1 and ST6GAL1 impacting the breakdown and synthesis of sialic acid derivatives. Additionally within immune response pathways SIAE influences the function of proteins involved in the regulation of immune cell signaling thereby affecting adaptive and innate immunity.
Researchers have connected SIAE with autoimmune diseases and certain neurodevelopmental disorders. Mutations or dysregulation in SIAE have been linked to conditions like systemic lupus erythematosus (SLE) and autism spectrum disorder (ASD). In the context of SLE SIAE's interaction with proteins like CTLA-4 impacts immune tolerance and autoreactivity. In ASD abnormal sialic acid modifications have implications for neurodevelopmental processes.