Abcam, ab162810, Recombinant Human RSBN1/Rosbin protein

Size: 10µg
Recombinant Human RSBN1/Rosbin protein is a Human Full Length protein, in the 1 to 411 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q5VWQ0,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Product details:
This product was previously labelled as RSBN1.

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RSBN1 also known as Rosbin encodes a protein involved in regulating structures within the cell nucleus. RSBN1 has a mass of approximately 94 kDa and is predominantly expressed in tissues with rapidly dividing cells such as the testis and certain cancerous tissues. This protein localizes mainly in the nucleoplasm indicating its role in nuclear processes. Its function and localization suggest it as a potential player in maintaining nuclear architecture and chromatin organization.
Biological function summary
The protein encoded by RSBN1 participates in chromatin remodeling which is essential for gene expression regulation and DNA replication. It acts as part of a larger chromatin-associated complex where it supports the structural changes needed for efficient transcription and replication processes. By modulating chromatin accessibility RSBN1 influences cell cycle progression affecting cell proliferation.
Pathways
RSBN1 plays a role in the chromatin organization pathway and cell cycle regulation. It interacts with histone modification enzymes facilitating the deposition of histone marks that modify chromatin structure. RSBN1 is associated with proteins like ATRX that have roles in chromatin remodeling and telomere maintenance contributing to genomic stability during cell division.
RSBN1 has shown a link to cancer progression particularly in testicular and digestive system cancers. Alterations in RSBN1 expression or function lead to disrupted chromatin organization resulting in uncontrolled cell proliferation a hallmark of cancer. The interaction with ATRX and other chromatin-modifying proteins further connects RSBN1 to these malignancies with potential implications in tumor progression and treatment resistance.