Abcam, ab162833, Recombinant Human Proprotein convertase PC4

Size: 10µg
Recombinant Human Proprotein convertase PC4 is a Human Full Length protein, in the 1 to 242 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q6UW60,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Proprotein convertase PC4 also known as PCSK4 is a serine protease that plays an important mechanistic role in the processing of proproteins. It has a molecular mass of approximately 59 kDa and processes precursor proteins into their active forms by cleaving at specific multibasic sites. PC4 is expressed in various tissues with significant levels found in reproductive tissues like the testis and ovary. By cleaving peptide precursors PC4 facilitates proper function and regulation of many proteins.
Biological function summary
Proprotein convertase PC4 is essential in the maturation of proteins involved in reproductive physiology. It is not part of a larger complex but functions independently to activate specific substrates. This protease participates in the processing of hormones and growth factors which are important for processes like fertilization and early embryonic development. PC4's activity ensures that the necessary proteins are available in their active forms at critical stages in development.
Pathways
PC4 operates within critical hormonal regulation and cell signaling pathways particularly those involved in reproduction. It is closely related to other proprotein convertases such as PC1/3 and PC2 which also play roles in hormone processing. The activity of PC4 influences the regulation of important reproductive hormones and signaling molecules ensuring appropriate cellular responses during reproductive events.
Proprotein convertase PC4 has been linked to infertility and certain reproductive disorders. Its malfunction may impact the processing of proteins important for reproductive success leading to these conditions. PC4's involvement in processing reproductive hormones connects it to proteins like inhibin and activin which play roles in fertility. Understanding PC4's function and regulation can provide insights into potential therapeutic approaches for reproductive health issues.