Abcam, ab16285, Anti-SSEA1 antibody [MC-480]

Size: 20µL-TRIAL / 200µL
Mouse Monoclonal FUT4 antibody. Suitable for IHC-FoFr, IHC-P, ICC, Flow Cyt and reacts with Human, Mouse samples. Cited in 77 publications.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:MC-480,
Isotype:IgM,
Light chain type:kappa,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-FoFr, Flow Cyt, ICC, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:We guarantee IHC-P in Human only

Product details:
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This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Purification notes-Tissue culture supernatant was cross flow concentrated., Storage buffer-Preservative: 0.02% Sodium azide Constituents: 99% Tissue culture supernatant, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Stage-specific embryonic antigen-1 (SSEA-1) also known as CD15 is a carbohydrate antigen often attached to glycoproteins or glycolipids. It has a molecular mass of approximately 480 Da. SSEA-1 is prominently expressed on the surface of murine embryonal carcinoma cells granulocytes and neural stem cells. It plays a role in cellular processes such as adhesion where it influences cell-to-cell and cell-to-extracellular matrix interactions.
Biological function summary
SSEA-1 participates in the regulation of cell differentiation and migration. This carbohydrate antigen is particularly critical in developmental stages where it impacts cellular behaviors that are important for embryogenesis. It functions as an adhesion molecule playing a role in forming complexes with cell surface lectins. These complexes can influence how cells communicate and adhere to one another therefore affecting various aspects of cellular dynamics.
Pathways
SSEA-1 is integral to the leukocyte extravasation signaling pathway which is significant for the immune system's operation. It interacts with proteins involved in the regulation of inflammation and immune response such as selectins. The antigen aids the tethering and rolling of leukocytes on endothelial surfaces a precursor step for their transmigration into tissues. SSEA-1's interaction with selectins is important in this process driving important cellular functions that enable immune surveillance and responses.
SSEA-1 is associated with certain cancers such as leukemia and neurological disorders. In leukemia SSEA-1 can act as a marker for cancer stem cells influencing tumor progression and resistance to chemotherapy. In the context of neurological disorders its altered expression is connected with the pathology of Alzheimer's disease where neural stem cell behavior may be affected. Other proteins like amyloid precursors potentially interact with SSEA-1 in Alzheimer's contributing to the disease's complexity.