Abcam, ab163604, Recombinant Human SLAIN2 protein

Size: 10µg
Recombinant Human SLAIN2 protein is a Human Full Length protein, in the 1 to 298 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q9P270,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SLAIN2 also known as SLAIN motif-containing protein 2 is a microtubule-associated protein with an approximate mass of 58 kDa. It localizes predominantly in the cytoplasm. SLAIN2 binds to microtubules directly and regulates their dynamics by influencing polymerization and depolymerization processes. It participates actively in controlling microtubule stability and cellular organization. Expression of SLAIN2 is widely observed across different tissues without restriction to a particular cell type.
Biological function summary
The protein modulates microtubule behavior by interacting with other microtubule plus-end tracking proteins such as those involved in spindle positioning and mitotic progression. SLAIN2 becomes part of complexes that contain proteins like Dishevelled EML1 and COL23A1 contributing to cellular functions that require dynamic cytoskeletal rearrangements. Its role extends to managing essential cellular activities such as cell division intracellular transport and cell migration.
Pathways
Microtubule dynamics regulated by SLAIN2 play a role in the Wnt signaling pathway and the cell cycle pathway. In the Wnt signaling pathway SLAIN2 interacts with proteins like APC and GSK3B. It aids in the proper alignment and segregation of chromosomes during mitosis in the cell cycle pathway facilitating appropriate cell cycle progression. These interactions help coordinate cellular proliferation and differentiation processes ensuring cell integrity and function.
SLAIN2 engages in processes linked to cancer and neurodegenerative diseases. Aberrations in its expression or function can lead to defects in cell cycle control or neuro underlying these conditions. It associates with proteins like TP53 in oncogenic pathways and tau protein in neurodegenerative pathways contributing to pathologies when microtubule dynamics become dysregulated. Understanding SLAIN2's function and connections daily could open new therapeutic avenues for related diseases.