Abcam, ab163923, Recombinant Human INTS3 protein

Size: 10µg
Recombinant Human INTS3 protein is a Human Full Length protein, in the 1 to 1042 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q68E01,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The INTS3 protein also known as Integrator Complex Subunit 3 plays a significant role in RNA processing. INTS3 has a molecular weight of approximately 113 kDa. Scientists have found its expression in various tissues indicating its widespread function in the body. INTS3 localizes to the nucleus where it takes part in essential cellular processes that maintain genomic stability.
Biological function summary
The INTS3 protein is a vital component of the Integrator complex which processes small nuclear RNAs (snRNAs) and involves RNA polymerase II. This complex oversees the 3'-end processing of snRNAs fundamental for regular RNA maturation and transcription. Adding to its biological roles INTS3 associates with other proteins to regulate DNA damage responses and repair pathways ensuring the integrity of genetic material.
Pathways
INTS3 actively engages in DNA damage response pathways and RNA splicing mechanisms. It works closely with proteins like MDC1 and BRCA1 in the DNA repair pathway facilitating efficient repair. In the RNA splicing pathway INTS3 contributes to snRNA biogenesis coordinating with other Integrator complex members to regulate gene expression post-transcriptionally.
Scientists link INTS3 dysfunction to cancer and immunological disorders. INTS3's role in DNA repair associates it with cancer as disruptions in repair pathways can lead to tumorigenesis. Additionally variations in INTS3 expression impact immune system function connecting it to certain immune-related disorders. The protein interacts with DNA repair and immune response proteins like PARP1 and p53 which further link it to disease mechanisms.