Abcam, ab164292, Recombinant Human INTS5 protein

Size: 10µg
Recombinant Human INTS5 protein is a Human Full Length protein, in the 1 to 1019 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q6P9B9,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
INTS5 also known as Integrator Complex Subunit 5 is a part of the Integrator complex. It has a molecular mass of approximately 110 kDa. This protein functions in the nucleus of cells where it plays an essential role in the processing of small nuclear RNA (snRNA). INTS5 is widely expressed across various tissues indicating its important role in many cellular processes.
Biological function summary
INTS5 is a component of the Integrator complex which is made up of several other subunits. This complex is responsible for the 3'-end processing of snRNA an important step in RNA maturation. By participating in these actions INTS5 and the Integrator complex contribute to the regulation of gene expression. Through these roles INTS5 helps maintain the proper function and stability of messenger RNA (mRNA) synthesis and processing.
Pathways
INTS5 plays an integral part in the RNA polymerase II transcription termination pathway. In this context the Integrator complex including INTS5 associates with the C-terminal domain of the RNA polymerase II enzyme. This association facilitates the proper termination and processing of snRNA transcripts. The complex frequently interacts with other proteins such as the Mediator complex emphasizing its role in fine-tuning RNA transcription processes.
Research links INTS5 with neurological diseases and cancer. Aberrations in the function or expression of INTS5 along with other subunits of the Integrator complex like INTS9 may contribute to transcriptional dysregulation linked to these conditions. This highlights the potential impact on pathways essential for cellular growth and differentiation suggesting a role for INTS5 in disease pathology particularly where transcriptional control is disrupted.