Abcam, ab164533, Recombinant Human FYTTD1 protein

Size: 10µg
Recombinant Human FYTTD1 protein is a Human Full Length protein, in the 1 to 318 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q96QD9,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FYTTD1 also known as UIF or U2AF65-interacting factor plays an essential role mechanically within the spliceosome. The protein has a molecular mass of approximately 63 kDa. FYTTD1 expresses widely across human tissues but shows higher expression in the nucleoplasm of cells. The protein facilitates interactions in pre-mRNA splicing by associating with other components of the spliceosomal complex which is critical for mRNA processing.
Biological function summary
FYTTD1 influences pre-mRNA splicing by forming part of the spliceosome complex. Research shows it interacts with U2AF65 a splicing factor necessary for promoting the assembly of the spliceosome complex on pre-mRNA. FYTTD1 ensures proper exon recognition and the removal of introns contributing to mRNA maturation. Its function is vital within the spliceosomal machinery maintaining the fidelity of gene expression.
Pathways
FYTTD1 supports efficient splicing and processing of pre-mRNA which directly affects mRNA transcript stability and protein synthesis pathways. It ties closely to the spliceosomal pathway and the gene expression regulation process. FYTTD1 works alongside proteins like U2AF65 and SF3B1 illustrating its participation in complex splicing mechanisms that regulate cellular metabolic activities and genome stability.
FYTTD1 is implicated in conditions such as cancer and neurodegenerative disorders. Abnormal splicing involving FYTTD1 can lead to aberrations in gene expression contributing to oncogenesis or faulty neuronal functioning. Studies link FYTTD1 dysregulation with changes in other proteins like SF3B1 and U2AF65 which exhibit altered activity in various cancers and neurological conditions highlighting the importance of its regulated expression.