Abcam, ab164675, Recombinant Human KLHL22 protein

Size: 10µg
Recombinant Human KLHL22 protein is a Human Full Length protein, in the 1 to 634 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q53GT1,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The target KLHL22 also known as kelch-like family member 22 is a protein that plays a significant role in cellular processes. KLHL22 consists of 623 amino acids and has a molecular mass of approximately 68 kDa. This protein is expressed in various tissues including the brain liver and kidney indicating its broad functional importance in the human body. KLHL22 functions as a component of a Cullin-RING E3 ubiquitin ligase complex where it facilitates the ubiquitination and subsequent degradation of specific protein substrates.
Biological function summary
KLHL22 is involved in regulating protein turnover by targeting proteins for ubiquitination influencing processes such as cell cycle progression and signal transduction. It operates as an adaptor protein within the Cullin-RING E3 ubiquitin ligase complex linking substrate proteins to the complex for ubiquitination. By regulating the degradation of key proteins KLHL22 impacts cellular homeostasis and various physiological responses demonstrating its importance in maintaining cellular order.
Pathways
KLHL22 contributes to the ubiquitin-proteasome pathway where it assists in protein degradation and turnover maintaining protein quality control. It also associates with the cell cycle regulation pathway interacting with proteins such as CUL3 within the Cullin-RING complex to ensure cell cycle progression by timely degradation of cyclins and other regulatory proteins. These pathway involvements highlight KLHL22's role in cellular regulation and proteostasis.
KLHL22 has been linked to neurological disorders and cancer. Abnormal expression or mutations in KLHL22 contribute to the development of certain neurodegenerative diseases with its disruption affecting neuronal protein homeostasis. Additionally its interaction with proteins like NRF2 is significant in cancer where altered ubiquitination regulates responses to oxidative stress. Understanding KLHL22's role in these conditions could offer insights into therapeutic targets for managing such diseases.